- Director: Tony Cervone
- Producer: Allison Abbate, Pam Coats
- Actors: Will Forte, Zac Efron, Mark Wahlberg, Amanda Seyfried, Jason Isaacs, Ken Jeong, Gina Rodriguez, Kiersey Clemons, Frank Welker, Simon Cowell
Shaggy and Scooby Doo are part of Mystery, Inc., joined by friends namely Velma (Gino Rodriguez), Fred (Zac Efron) and finally Daphne (Amanda Seyfried) as they drove around town in the Mystery Machine looking for supernatural evil to be resolved.
But things are getting stale for the unit, which is looking for investors to be able to bring their small-town business to big time. For Shaggy and Scooby Doo the problem has just begun to be immediately targeted for collection by a man named Dick Dastardly (Jason Isaacs) who hunts the skull of a giant dog to be able to reach the golden wealth located in the underworld.
Saving the day is Dynomutt (Ken Jeong), Dee Dee Sykes (Kiersey Clemons) and finally Blue Falcon (Mark Wahlberg) who takes friends who are not scared, giving superhero dogs a superhero makeover superhero when they accelerate to be able to thwart the destructive plans of Dick Dastardly .